If this game were played in November the Bills would be in trouble but they are catching the Colts at the right time.  The Colts will likely treat this game like the 4th pre-season game getting the starters in and out really quick.  With Dwight Freeney and Robert Mathis likely both sitting this game out the Bills should have time to throw the football.  They are hoping that Ryan Fitzpatrick can give it a go in this game.  The Bills will likely try to throw to get the lead and then try to grind out a win on the ground with Fred Jackson and Marshawn Lynch.

Defensively the Bills had better be ready to stop rookie RB Donald Brown who will likely be the focal point of the Colts’ offense this week.  That could be bad news for the Bills as they are allowing 165.1 yards rushing and 4.8 yards per carry this season.  The Bills will need to put pressure on rookie QB Curtis Painter who made some huge mistakes against the Jets last weekend leading the Colts to their first loss of the year.

PREDICTION:  BILLS 20, COLTS 14

The Buffalo Bills appear to be in trouble in this game as it is looking like Brian Brohm will get his first NFL start.  That means the Bills will likely turn to Fred Jackson and Marshawn Lynch to carry the load on offense.  The Falcons are allowing 116.5 yards rushing and 4.2 yards per carry this season but they will likely have an extra defender or two in the box to deal with the run.  That would force the Bills to attack the Falcons’ secondary which is their weak point.  However, Bills’ QBs have been sacked 44 times already this season which means that Brohm will have to make quick decisions.  It is still possible that Ryan Fitzpatrick could play in this game but it’s very unlikely.

Even with Michael Turner out of action the Falcons will likely try to run a balanced offense as Jason Snelling could have a big game against a Bills’ D that is allowing 165.6 yards rushing and 4.8 yards per carry this year.  Still, the Bills must worry about stopping Matt Ryan, Tony Gonzalez and Roddy White if they want to compete in this football game and that will be easier said than done without safety Jairus Byrd.

PREDICTION:  FALCONS 33, BILLS 13

The Buffalo Bills (5-8) are hosting the New England Patriots (8-5) this week, and they are trying to end a 12 game losing streak against the Pats.  They nearly won against the Patriots in week one, but that was when Tom Brady was still getting his game back.  Brady has been battling some injuries lately though, so hopefully he wont be full strength on Sunday.  The Patriots will likely run the ball a lot either way, as the Bills have been awful at stopping the run.  They need to do a much better job than the 170 yard average they are giving up this year.  Patriots’ running back Laurence Maroney will make them pay if they don’t get some penetration and clog up some holes.

Ryan Fitzpatrick has to play better than what he has been showing the last two games.  He failed to reach 100 yards passing in both of those games, and if he does that again they will not win.  Hopefully Terrell Owens will be able to play in this one, as he and Fitzpatrick have been hooking up for some big plays.  TO is listed as questionable though, battling an illness.  Fred Jackson and Marshawn Lynch have been running the ball well as of late, so they should be able to do some damage against the Pats run defense.  They are still the Patriots though, and as long as they have Tom Brady, Randy Moss, and Wes Welker they will be successful against the Bills.

FINAL SCORE PREDICTION:  Buffalo Bills 14, New England Patriots 24

This should be one of the more entertaining games of week #13 in the NFL.  The Bills will likely come out running the ball with Fred Jackson and Marshawn Lynch against a Chiefs’ D that is allowing 143.8 yards rushing and 4.4 yards per carry this year.  Don’t think for a minute that the Bills won’t be passing more than usual against a Chiefs’ D that is allowing 250.8 yards passing per game.  Terrell Owens and Lee Evans should have field days this Sunday against the Chiefs as long as Ryan Fitzpatrick has the time to get the ball downfield.

The Chiefs will also likely have the same type of gameplan against the Bills.  The Bills are allowing 172.1 yards rushing and 4.9 yards per game so look for Jamaal Charles to likely have the game of his life on Sunday.  But, the Bills will likely try to blitz Matt Cassel into making some big mistakes like he has done the last two weeks.  After all, the Bills do have 21 interceptions already this year.

PREDICTION:  BILLS 30, CHIEFS 27

The Bills won the first match-up between these two teams 16-13 in OT in New Jersey.  For the Jets to get a win to even the series then Mark Sanchez must protect the football as he threw 5 pickoffs in the first game against the Bills.  The Bills are allowing 165.1 yards rushing per game and 4.8 yards per carry so look for the Jets to come out running against them.  After all, they did rush for 318 yards in the first game against the Bills this year.  Thomas Jones and Shonn Greene should have good games tomorrow against the Bills running the ball.  With ballhawking safeties like the Bills have look for Mark Sanchez to be careful when throwing the ball to TE Dustin Keller.  The Bills will likely double cover Jerricho Cotchery and make Braylon Edwards beat them in the passing game.

The Bills will likely try to mix things up on offense this week.  The Jets have a really good secondary especially CB Darrelle Revis who will likely be following the suddenly hot Terrell Owens all over the field.  That means that Lee Evans has to step up this week or Ryan Fitzpatrick could have trouble throwing the football.  The X-factor in this game is RB Fred Jackson who had a solid game last week as the main man in the running game.  He will challenge the linebackers of the Jets both running and catching the ball out of the backfield.

PREDICTION:  JETS 16, BILLS 14