The Buffalo Bills have lost Fred Jackson (broken left hand) for the next 4-6 weeks and Marshawn Lynch for the next 3-4 weeks due to an ankle sprain.  Jackson carried the ball 2 times for 11 yards (5.5 ypc) in the pre-season opener while Lynch caught 1 pass for 12 yards.  The Bills will likely showcase rookie C.J. Spiller the rest of the pre-season.  He carried the ball 4 times for 16 yards (4.0 ypc) in the first game of the pre-season.  Look for Chad Simpson to also have a increased workload due to the injuries to Jackson and Lynch.  The Bills hope that Jackson & Lynch will be ready to go by the regular season opener.