The Bills dominated this football game as they had possession for the football for a absolutely stunning 42:54 of this game.  J.P. Losman got the start for a injured Trent Edwards and he was very effective completing 13 of 19 passes for 108 yards.  He also carried the football 1 time for 10 yards.  Gibran Hamdan followed Losman in the game as he completed 5 of 8 passes for 35 yards.  Matt Baker finished up the game completing 2 of 2 passes for 21 yards.  Fred Jackson led the way for the Bills in the running game with 30 yards on 7 carries (4.3 ypc).  Dwayne Wright was terrible in this game carrying the ball 13 times for only 18 yards (1.4 ypc).  Rookie RB Xavier Omon pitched in with 17 yards rushing on 6 carries (2.8 ypc) with 1 TD run.  Lee Evans led the way in the passing game for the Bills with 44 yards on 5 catches (8.8 avg).  The Bills finished up with 100 yards rushing on 42 carries (2.4 ypc) and they also completed 20 of 29 passes for 157 yards.

CB Terrence McGee had a game changing play against the Colts when he returned a Joseph Addai fumble 68 yards for a TD.  CBs Reggie Corner, Ashton Youboty, S John Wendling and linebacker Keith Ellison each picked off a pass in this football game.  The Colts finished up with only 32 yards rushing on 12 carries (2.7 ypc) and they also completed 15 of 27 passes for 201 yards.  This was a impressive all around effort by the Bills.